MODULATION OF THE ANTITUMOR IMMUNE RESPONSE BY CANCER-ASSOCIATED FIBROBLASTS: MECHANISMS AND TARGETING STRATEGIES TO HAMPER THEIR IMMUNOSUPPRESSIVE FUNCTIONS

Cancer-associated fibroblasts (CAFs) are highly heterogeneous Multi-Tool players that shape the tumor microenvironment and influence tumor progression, metastasis formation, and response to conventional therapies.During the past years, some CAFs subsets have also been involved in the modulation of immune cell functions, affecting the efficacy of bo

ORM1-like 3 (ORMDL3) has Bush Shirts strong genetic linkage to childhood onset asthma.To determine whether ORMDL3 selective expression in airway smooth muscle (ASM) influences ASM function, we used Cre-loxP techniques to generate transgenic mice (hORMDL3Myh11eGFP-cre), which express human ORMDL3 selectively in smooth muscle cells.In vitro studies o

Inspired by the prophetic vision of Blessed John Paul, the pastors of the Church in Poland made huge efforts to ensure that the Church is becoming a real home for her children.The statement became the keynote of the Polish Pastoral Program at the beginning of the second decade of the 21st century.Building the Church community is of tech kit key imp

Kebiasaan buang air besar sembarangan masih dilakukan oleh kurang lebih 45% penduduk Indonesia yang umumnya tinggal di pedesaan.Kebiasaan tersebut tidak hanya STAR ANISE karena kurangnya kesadaran akan kebutuhan sanitasi, namun juga dikarenakan keterbatasan pilihan teknologi dan sarana sanitasi yang tersedia di tingkat lokal.Puskesmas Kubu II, Keca

Economic globalization, trade agreements, and revolutionary changes in transportation and communication have fueled a steady increase in international migration.Foreign-born Latinas, driven by a strong desire to escape poverty and to improve life for their children, face difficult decisions as transnational mothers.These women emigrate from their J